Keserû, György M.: search on Z-Library

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1

Expanding the medicinal chemistry synthetic toolbox

Boström, Jonas, Brown, Dean G., Young, Robert J., Keserü, György M.

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 1.23 MB

english, 2018

2

Design principles for fragment libraries – Maximizing the value of learnings from Pharma fragment based drug discovery (FBDD) programs for use in academia

Keseru, Gyorgy M, Erlanson, Daniel Andrew, Ferenczy, Gyorgy G, Hann, Michael M., Murray, Christopher W, Pickett, Stephen D.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

3

Conformational analysis of a condensed macrocyclic β-lactam by NMR and molecular dynamics calculations

György M. Keseru&amp, #x030B, , Helga Vásárhelyi, Gergely Makara

Journal:

Journal of Molecular Structure

Year:

1994

Language:

english

File:

PDF, 329 KB

english, 1994

4

Thermodynamics guided lead discovery and optimization

György G. Ferenczy, György M. Keserű

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 911 KB

english, 2010

5

Structure-based discovery and binding site analysis of histamine receptor ligands

Kiss, Róbert, Keserű, György M.

Journal:

Expert Opinion on Drug Discovery

Year:

2016

Language:

english

File:

PDF, 1.49 MB

english, 2016

6

Comparative Evaluation of Covalent Docking Tools

Scarpino, Andrea, Ferenczy, Gyorgy G, Keserű, György M

Journal:

Journal of Chemical Information and Modeling

Year:

2018

Language:

english

File:

PDF, 3.20 MB

english, 2018

7

Identification of 8-Hydroxyquinoline Derivatives Active Against Somatic V658F Mutant JAK1-Dependent Cells

Kiss, Róbert, Bajusz, Dávid, Baskin, Rebekah, Tóth, Katalin, Monostory, Katalin, Sayeski, Peter P., Keserű, György M.

Journal:

Archiv der Pharmazie

Year:

2016

Language:

english

File:

PDF, 1.41 MB

english, 2016

8

Synthesis of Acerogenin C and (+)-Acerogenin A, Two Macrocyclic Diarylheptanoid Constituents of Acer nikoense

György Miklós Keserü, Mihály Nógrádi, Áron Szöllösy

Journal:

European Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 374 KB

english, 1998

9

In Silico and Ex Silico ADME Approaches for Drug Discovery

Darvas, Ferenc, Keseru, Gyorgy, Papp, Akos, Dorman, Gyorgy, Urge, Laszlo, Krajcsi, Peter

Journal:

Current Topics in Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 332 KB

english, 2002

10

Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise; Implications for Structure-Based Drug Design

Menyhard, Dora, Keseru, Gyorgy, Naray-Szabo, Gabor

Journal:

Current Computer - Aided Drug Design

Year:

2009

Language:

english

File:

PDF, 550 KB

english, 2009

11

Solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines

Csaba Wéber, Attila Bielik, Ádám Demeter, István Borza, Györgyi I. Szendrei, György M. Keserű, István Greiner

Journal:

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

12

Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas

Orlova, Anna, Wingelhofer, Bettina, Neubauer, Heidi A., Maurer, Barbara, Berger-Becvar, Angelika, Keserű, György Miklós, Gunning, Patrick T., Valent, Peter, Moriggl, Richard

Journal:

Expert Opinion on Therapeutic Targets

Year:

2017

Language:

english

File:

PDF, 1.78 MB

english, 2017

13

Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor

Frank, Annika, Kiss, Dóra J., Keserű, György M., Stark, Holger

Journal:

Scientific Reports

Year:

2018

File:

PDF, 4.31 MB

2018

14

Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands

Rataj, Krzysztof, Kelemen, Ádám, Brea, José, Loza, María, Bojarski, Andrzej, Keserű, György

Journal:

Year:

2018

Language:

english

File:

PDF, 7.15 MB

english, 2018

15

Diastereoselectivity in the formation of bicyclic cyclopropane carboxylic acid lactones

Zoltán Hell, Zoltán Finta, Tamás Grünvald, Zsolt Böcskei, Daniella Balán, György M. Keseru&amp, #x030B, , László To&amp, #x030B, ke

Journal:

Year:

1999

Language:

english

File:

PDF, 518 KB

english, 1999

16

Effect of a trifluoromethyl group on molecular structure: Competitive mono- and dilithiation of 1-[(trifluoromethyl)phenyl]pyrroles

Ferenc Faigl, Katalin Fogassy, Erzsébet Szűcs, Krisztina Kovács, György M Keserű, Veronika Harmat, Zsolt Böcskei, László Tőke

Journal:

Year:

1999

Language:

english

File:

PDF, 697 KB

english, 1999

17

Enantiomeric recognition of α-(1-naphthyl)ethylammonium perchlorate by enantiomerically pure dimethylphenazino-18-crown-6 ligand in solid and gas phases

Tı́mea Gérczei, Zsolt Böcskei, György M Keserű, Erika Samu, Péter Huszthy

Journal:

Tetrahedron: Asymmetry

Year:

1999

Language:

english

File:

PDF, 344 KB

english, 1999

18

Aspartic acid scaffold in bradykinin B1 antagonists

József Huszár, Zoltán Timár, Ferenc Bogár, Botond Penke, Róbert Kiss, Krisztina Katalin Szalai, Éva Schmidt, Andrea Papp, György Keserű

Journal:

Journal of Peptide Science

Year:

2009

Language:

english

File:

PDF, 482 KB

english, 2009

19

Disruption ofSCO5461gene coding for a mono-ADP-ribosyltransferase enzyme produces a conditional pleiotropic phenotype affecting morphological differentiation and antibiotic production inStreptomyces coelicolor

Krisztina Szirák, Judit Keserű, Sándor Biró, Iván Schmelczer, György Barabás, András Penyige

Journal:

Journal of Microbiology

Year:

2012

Language:

english

File:

PDF, 530 KB

english, 2012

20

Prediction of antibacterial activity of some diarylheptanoids isolated from Garuga species by molecular mechanics and molecular orbital calculations

György Miklós Keserü, Mihály Nógrádi

Journal:

Journal of Molecular Structure: THEOCHEM

Year:

1993

Language:

english

File:

PDF, 572 KB

english, 1993

21

Is there a link between selectivity and binding thermodynamics profiles?

Tarcsay, Ákos, Keserű, György M.

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 677 KB

english, 2015

22

Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease

Oláh, Judit, Orosz, Ferenc, Keserü, György M., Kovári, Zoltán, Kovács, János, Hollán, Susan, Ovádi, Judit

Journal:

Biochemical Society Transactions

Year:

2002

Language:

english

File:

PDF, 1.45 MB

english, 2002

23

The impact of binding site waters on the activity/selectivity trade-off of Janus kinase 2 (JAK2) inhibitors

Egyed, Attila, Bajusz, Dávid, Keserű, György M.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2019

File:

PDF, 2.48 MB

2019

24

The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu5 receptor case study

Orgován, Zoltán, Ferenczy, György G., Keserű, György M.

Journal:

Journal of Computer-Aided Molecular Design

Year:

2019

Language:

english

File:

PDF, 1.25 MB

english, 2019

25

Catalytic Mechanism and Covalent Inhibition of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA): Implications to the Design of Novel Antibacterials

Mihalovits, Levente M, Ferenczy, György G, Keserű, György M

Journal:

Journal of Chemical Information and Modeling

Year:

2019

Language:

english

File:

PDF, 1.67 MB

english, 2019

26

Synthesis of Garugamblin-2, a Macrocyclic Diarylheptanoid Constituent of Garuga gamblei

György M. Keserü, Mihály Nógrádi, Mária Kajtár-Peredy

Journal:

European Journal of Organic Chemistry

Year:

1994

Language:

english

File:

PDF, 398 KB

english, 1994

27

Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile

Éva Ágai-Csongor, Katalin Nógrádi, János Galambos, István Vágó, Attila Bielik, Ildikó Magdó, Györgyi Ignácz-Szendrei, György Miklós Keserű, István Greiner, István Laszlovszky, Éva Schmidt, Béla Kiss,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 287 KB

english, 2007

28

Identification of Nitric Oxide Donors by Biomimetic HTS Application

Balogh, Gyorgy, Dalmadi, Balazs, Bielik, Attila, Keseru, Gyorgy

Journal:

Combinatorial Chemistry & High Throughput Screening

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

29

Property-based characterization of kinase-like ligand space for library design and virtual screening

Bajusz, David, Ferenczy, Gyorgy, Keserû, George M

Journal:

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

30

Discovery of d -amino acid oxidase inhibitors based on virtual screening against the lid-open enzyme conformation

Szilágyi, Bence, Skok, Žiga, Rácz, Anita, Frlan, Rok, Ferenczy, György G., Ilaš, Janez, Keserű, György M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

31

Spiro[pyrrolidine-3,3′-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes

Kelemen, Ádám, Satala, Grzegorz, Bojarski, Andrzej, Keserű, György

Journal:

Year:

2017

Language:

english

File:

PDF, 9.24 MB

english, 2017

32

Synthesis and Conformational Analysis of Dicationic N,N′-Bridged Bis(benzimidazolium) and Bis(imidazolium) Macrocycles

István Bitter, Zsolt Török, Viktor Csokai, Alajos Grün, Barbara Balázs, Gábor Tóth, György M. Keserű, Zoltán Kovári, Mátyás Czugler

Journal:

European Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 427 KB

english, 2001

33

Optimization of virtual screening protocols: FlexX based virtual screening for COX-2 inhibitors reveals the importance of tailoring screen parameters

András Bauer, Zoltán Kovári, György M. Keserű

Journal:

Journal of Molecular Structure: THEOCHEM

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

34

Metalloporphyrin catalyzed oxidation of n-hydroxyguanidines: a biomimetic model for the H2O2-dependent activity of nitric oxide synthase

György M Keserű, György T Balogh, Tamás Karancsi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 107 KB

english, 2000

35

Antioxidant activity-guided phytochemical investigation of Artemisia gmelinii Webb. ex Stechm.: Isolation and spectroscopic challenges of 3,5-O-dicaffeoyl (epi?) quinic acid and its ethyl ester

Árpád Könczöl, Zoltán Béni, Márta Meszlényi Sipos, Attila Rill, Viktor Háda, Judit Hohmann, Imre Máthé, Csaba Szántay Jr., György Miklós Keserű, György Tibor Balogh

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

36

The Jak2 Inhibitor, G6, Alleviates Jak2-V617F–Mediated Myeloproliferative Neoplasia by Providing Significant Therapeutic Efficacy to the Bone Marrow

Kirabo, Annet, Park, Sung O., Majumder, Anurima, Gali, Meghanath, Reinhard, Mary K., Wamsley, Heather L., Zhao, Zhizhuang Joe, Cogle, Christopher R., Bisht, Kirpal S., Keserű, György M., Sayeski, Pete

Journal:

Year:

2011

Language:

english

File:

PDF, 1.93 MB

english, 2011

37

Cytochrome P450 Catalyzed Nitric Oxide Synthesis: A Theoretical Study

Keserü, György M., Volk, Balázs, Balogh, György T.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2000

Language:

english

File:

PDF, 952 KB

english, 2000

38

On the enthalpic preference of fragment binding

Ferenczy, György G., Keserű, György M.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.62 MB

english, 2016

39

Comparative Evaluation of in Silico pKa Prediction Tools on the Gold Standard Dataset

György T. Balogh, Benjámin Gyarmati, Balázs Nagy, László Molnár, György M. Keserű

Journal:

Molecular Informatics

Year:

2009

Language:

english

File:

PDF, 353 KB

english, 2009

40

Special issue in flow chemistry

György M. Keserű, György Dormán

Journal:

Molecular Diversity

Year:

2011

Language:

english

File:

PDF, 59 KB

english, 2011

41

On the anomalous behaviour of certain 1-(4-methoxyphenyl)azetidin-2-ones towards cerium(IV) ammonium nitrate (CAN). Structure-reactivity studies

Attila Sápi, Ferenc Bertha, József Fetter, Mária Kajtár-Peredy, György M Keserű, Károly Lempert

Journal:

Year:

1996

Language:

english

File:

PDF, 558 KB

english, 1996

42

Thermodynamics of Fragment Binding

Ferenczy, György G., Keserű, György M.

Journal:

Journal of Chemical Information and Modeling

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

43

A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth

Anurima Majumder, Andrew T. Magis, Sung O. Park, Nicholas C. Figueroa, Rebekah Baskin, Annet Kirabo, Robert W. Allan, Zhizhuang Joe Zhao, Kirpal S. Bisht, György M. Keserű, Peter P. Sayeski

Journal:

Experimental Hematology

Year:

2012

Language:

english

File:

PDF, 1.34 MB

english, 2012

44

On the Conformation of Tiazofurin Analogues

Makara, Gergely M., Keserû, György M.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 436 KB

english, 1997

45

Solid-phase synthesis of an N-(phenylalkyl)cinnamide library via Horner–Wadsworth–Emmons reaction

Csaba Wéber, Attila Bielik, Györgyi I. Szendrei, György M. Keserû, István Greiner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 139 KB

english, 2004

46

Novel bradykinin-1 antagonists containing a (1,2,3,4-tetrahydro-isoquinolin-1-yl)acetic acid scaffold

József Huszár, Zoltán Timár, Krisztina Katalin Szalai, György Keserű, Ferenc Fülöp, Botond Penke

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 353 KB

english, 2008

47

Homology modelling and binding site mapping of the human histamine H1 receptor

Róbert Kiss, Zoltán Kovári, György M. Keserű

Journal:

European Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 655 KB

english, 2004

48

A hypothetical mechanism for HIV-1 integrase catalytic action: DFT modelling of a bio-mimetic environment

Fernando Bernardi, Andrea Bottoni, Marco De Vivo, Marco Garavelli, György Keserü, Gábor Náray-Szabó

Journal:

Chemical Physics Letters

Year:

2002

Language:

english

File:

PDF, 207 KB

english, 2002

49

Site of metabolism prediction on cytochrome P450 2C9: a knowledge-based docking approach

Ákos Tarcsay, Róbert Kiss, György M. Keserű

Journal:

Journal of Computer-Aided Molecular Design

Year:

2010

Language:

english

File:

PDF, 503 KB

english, 2010

50

Hit discovery and hit-to-lead approaches

György M. Keserű, Gergely M. Makara

Journal:

Drug Discovery Today

Year:

2006

Language:

english

File:

PDF, 243 KB

english, 2006

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